Platform Overview
YanGeneBio has integrated industry-leading drug target fishing technologies to build a multi-technology collaborative platform covering the full chain from "target discovery – interaction analysis – functional validation." Each technology has its own strengths and can be flexibly selected or combined based on project needs.
Core Technology Matrix
| Technology | Principle | Best For |
|---|---|---|
| ABPP | Covalent probe labeling of active proteins | Enzyme target discovery |
| LiP-MS | Conformational change peptide fingerprinting | De novo unknown target discovery |
| CETSA | Thermal stability shift | In-cell target validation |
| Spider Biotin | High-affinity biotin capture | Natural product target fishing |
Synergistic Advantages
- Cross-validation: Multiple independent technologies pointing to the same target greatly increases confidence
- Complementary coverage: ABPP for enzymes, LiP-MS for global screening, CETSA for in-cell validation
- One-stop delivery: Seamless workflow from sample receipt to data analysis report