3 article(s) in total
source of literature：Huang Y, Hou L, He R, Zhu L, et al. *Scaling Covalent Ligand Discovery through Dynamic Combinatorial Library-versus-Proteome Screening.* Nature Communications, 2026 Jun 19. DOI: 10.1038/s41467-026-74672-y
Introduction: Multi-Omics Empowers Deciphering the Metabolic Code of Adenoma-to-Carcinoma Progression Colorectal cancer (CRC) is a highly prevalent malignant tumor of the digestive tract worldwide. Its progressive trajectory from "normal epithelium–adenoma–carcinoma" provides a valuable time window for early intervention and screening. However, the serum carcinoembryonic antigen (CEA) and fecal immunochemical test (FIT) commonly used in clinical practice have limitations in both sensitivity and specificity. In August 2024, a landmark study published in the top-tier journal Cancer Cell—based on 1,251 samples from four independent cohorts—systematically mapped the panoramic metabolome landscape during CRC progression by integrating plasma and fecal untargeted/targeted metabolomics, metagenomic sequencing, and cytokine profiling. The study not only precisely identified oleic acid and allocholic acid (别胆酸) as key functional metabolites, but also dissected their underlying mechanisms in depth and constructed a plasma metabolite panel with high diagnostic performance, thereby providing a novel technical path and theoretical basis for the early screening of CRC.
Postmenopausal osteoporosis is a major health challenge faced by middle-aged and elderly populations worldwide, with its core pathology being the overactive bone resorption function of osteoclasts. Nrf2 (nuclear factor E2 related factor 2), as a key antioxidant transcription factor, has been found to play a "braking" role in bone metabolism regulation in recent years. However, existing Nrf2 activators (such as dimethyl fumarate DMF) are difficult to safely use in chronic diseases due to dose limiting hepatotoxicity and adverse reactions. Reference knowledge terminology database+add memory database Knowledge database Internet search terminology 165/1000PDF translation and formatting retention, recommended to use document translation AI translation Postmenopausal osteoporosis is a major health challenge faced by middle-aged and elderly populations worldwide, with its core pathology being the overactive bone resorption function of osteoclasts. Nrf2 (nuclear factor E2 related factor 2), as a key antioxidant transcription factor, has been found to play a "braking" role in bone metabolism regulation in recent years. However, existing Nrf2 activators (such as dimethyl fumarate DMF) are difficult to safely use in chronic diseases due to dose limiting hepatotoxicity and adverse reactions. Reference knowledge terminology database+add memory database knowledge database networking search terminology 165/1000PDF translation retention layout, recommended to use document translation AI translation transfer AI big model translation ai_ advanced common AI big model translation machine translation, general field machine translation, academic paper machine translation, biopharmaceutical machine translation, information technology machine translation, financial and economic machine translation, news and information machine translation, aerospace machine translation, mechanical manufacturing machine translation, legal and regulatory machine translation, contract document machine translation, humanities and social science certification enterprise edition, unlock AI flagship big model Postmenopausal osteoporosis is a significant health challenge faced by the middle-aged and elderly population worldwide, with its core pathology being the excessive hyperactivity of osteoclast bone resorption. Nrf2 (nuclear factor erythroid 2-related factor 2), as a key antioxidant transcription factor, has recently been found to play a "braking" role in bone metabolism regulation. However, existing Nrf2 activators (such as dimethyl fumarate DMF) are difficult to safely apply in chronic diseases due to dose-limiting hepatotoxicity and adverse effects. Translate AI models into AI, including machine translation, general domain machine translation, academic paper machine translation, biopharmaceutical machine translation, information technology machine translation, financial and economic machine translation, news and information machine translation, aerospace machine translation, mechanical manufacturing machine translation, legal and regulatory machine translation, contract document machine translation, and humanities and social science certification enterprise edition. Unlock AI flagship models Postmenopausal osteoporosis is a significant health challenge faced by the middle-aged and elderly population worldwide, with its core pathology being the excessive hyperactivity of osteoclast bone resorption. Nrf2 (nuclear factor erythroid 2-related factor 2), as a key antioxidant transcription factor, has recently been found to play a "braking" role in bone metabolism regulation. However, existing Nrf2 activators (such as dimethyl fumarate DMF) are difficult to safely apply in chronic diseases due to dose-limiting hepatotoxicity and adverse effects. 划译 Postmenopausal osteoporosis is a significant health challenge faced by the middle-aged and elderly population worldwide, with its core pathology being the excessive hyperactivity of osteoclast bone resorption. Nrf2 (nuclear factor erythroid 2-related factor 2), as a key antioxidant transcription factor, has recently been found to play a "braking" role in bone metabolism regulation. However, existing Nrf2 activators (such as dimethyl fumarate DMF) are difficult to safely apply in chronic diseases due to dose-limiting hepatotoxicity and adverse effects.