Expertise
YanGeneBio possesses a comprehensive oligonucleotide drug R&D service platform, providing full-chain technical services from sequence design, chemical modification, scale-up synthesis to functional validation.
Core Service Modules
- Sequence design & optimization: siRNA/ASO design algorithms, off-target prediction, species specificity analysis
- Chemical modification & synthesis: Multiple modification types (2'-OMe/2'-F/PS/LNA), Class 100,000 clean lab ensures quality
- Purification & QC: HPLC/UHPLC purification, LC-MS QA, fully automated purification platform
- Functional validation: Transfection optimization, knockdown efficiency (qPCR/Western Blot), phenotypic analysis
- Delivery solutions: LNP, GalNAc conjugation, exosome and other delivery strategy consulting
Technical Specifications
- Synthesis throughput: 800–1,200 siRNAs/day
- Scale: 10 µg – 10 g
- Purity guarantee: ≥ 95% (HPLC)
- Turnaround: 3–5 business days (standard)