Overview
Antisense Oligonucleotides (ASOs) are short nucleic acid molecules that regulate gene expression through Watson-Crick base pairing with target mRNAs. We provide end-to-end services from sequence design to scale-up synthesis.
Chemical Modification Options
- Backbone modification: Phosphorothioate (PS), Boranophosphate (BP)
- Sugar modification: 2'-OMe, 2'-F, 2'-MOE, LNA (Locked Nucleic Acid)
- Terminal modification: 5'/3' conjugation (cholesterol, GalNAc, PEG, etc.)
- Mixed backbone: Gapmer design (DNA gap + modified wings)
Synthesis Specifications
- Length range: 12–30 nt
- Scale: 10 µg – 10 g
- Purity grade: HPLC purified (> 95%) or PAGE grade
- QC standard: LC-MS MW confirmation + HPLC purity analysis